3H-PYRAZOL-3-ONE, 1,2-DIHYDRO-
3H-PYRAZOL-3-ONE, 1,2-DIHYDRO-
CAS: 137-45-1
Molecular Formula: C3H4N2O
3H-PYRAZOL-3-ONE, 1,2-DIHYDRO- - Names and Identifiers
3H-PYRAZOL-3-ONE, 1,2-DIHYDRO- - Physico-chemical Properties
| Molecular Formula | C3H4N2O |
| Molar Mass | 84.0767 |
| Density | 1.191±0.06 g/cm3(Predicted) |
| Melting Point | 160-162 °C |
| Boling Point | 326.1℃ at 760mmHg |
| pKa | 9.00±0.70(Predicted) |
| Storage Condition | 2-8°C |
| Physical and Chemical Properties | Uses 1, 2-dihydro-3H-pyrazole -3-one, also known as 1H-pyrazole -3(2H)-one, is an organic intermediate, which can be made of methyl propionate or ethyl acrylate Or (2E)-3-methoxyacrylate is prepared by one-step ring closing. |
3H-PYRAZOL-3-ONE, 1,2-DIHYDRO- - Upstream Downstream Industry
| Downstream Products | 1-(4-CHLOROPHENYL)-3-HYDROXY-1H-PYRAZOLE |
3H-PYRAZOL-3-ONE, 1,2-DIHYDRO- - Preparation
hydrazine hydrate (3.6mL,47.58mmol,1 equivalent) was added dropwise to methanol (40mL) solution of methyl propionate (4.2mL,47.58mmol,1 equivalent) at 0 ℃. The reaction mixture was stirred at room temperature for 30 minutes. Add salt water (10mL) and then remove methanol under vacuum. The remaining water layer was extracted with EtOAc(4*75mL). The combined organic phase was dried with anhydrous MgSO4, filtered and concentrated in vacuum to give the title compound 1, 2-dihydro-3H-pyrazol-3-one as a white solid (3.2g,78% yield).
Last Update：2024-04-10 22:29:15
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Downstream Products for 3H-PYRAZOL-3-ONE, 1,2-DIHYDRO-